Cyclic GMP Phosphodiesterases and Regulation of Smooth Muscle Function
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چکیده
منابع مشابه
Phosphodiesterases and cyclic GMP regulation in heart muscle.
The cyclic nucleotide cGMP and its corresponding activated kinase cGK-1 serve as a counterbalance to acute and chronic myocardial stress. cGMP hydrolysis by several members of the phosphodiesterase (PDE) superfamily, PDE1, PDE2, and PDE5, regulate this signaling in the heart. This review details new insights regarding how these PDEs modulate cGMP and cGK-1 to influence heart function and chroni...
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Papaverine, a nonspecific smooth muscle relaxant, is well known to be a potent cyclic AMP phosphodiesterase inhibitor (1, 2). In recent papers (3-8) it has been reported that smooth muscle relaxing action of papaverine is likely to be mediated through an increase of cyclic AMP due to its phosphodiesterase inhibition. Recently attention has drawn to the role of cyclic GMP, which often presents p...
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Marston, S. B. & Smith, C. W. J. (1984)J. Muscle Res. 5,559-575 Marston. S. B. & Smith, C. W. J. (1 985) J. Muscle Res. 6,669-708 Marston, S. B., Lehman, W., Moody. C. & Pritchard, K. ( 1 988) in Calcium and Calcium binding Proteins (Gerday, C., Gilles, R. & Bolis, L., eds.). pp. 69-8 1, Springer Verlag, Heidelberg Mathew, J. K., Krolak, J. M. & Dedman, J. R. ( 1 986) J. Cell. Biochem. 32,223-2...
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The mechanisms regulating altered airway smooth muscle (ASM) cell tone and airway reactivity in asthma remain incompletely understood. For vascular smooth muscle (VSM), the most important endogenous relaxation pathway is the nitric oxide (NO)-guanylate cyclase-cyclic GMP-dependent protein kinase type I (PKGI) pathway in which endogenous NO from NO synthases or from exogenous nitrovasodilators a...
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ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000087541.15600.2b